About 21 results found for searched term "ERK2 IN-1" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14152 | ERK1/2 inhibitor 1 | ERK |
| ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively. | ||
| M49706 | ERK2 IN-1 | ERK |
| ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM. | ||
| M4469 | Cinnamaldehyde | PPAR |
| Cinnamaldehyde is a naturally occurring flavonoid found in the bark of Cinnamomum cinnamomi and other Cinnamomum species such as camphor and cinnamon, and can act through a variety of signaling pathways, including PPARs, AMPK, PI3K/IRS-1, RBP4-GLUT4, ERK/JNK/p38MAPK, TRPA1-ghrelin, and the Nrf2 pathways.Cinnamaldehyde also has the potential to modulate the activities of PTP1B and α-amylase with antifungal activity and antioxidant activity. | ||
| M6160 | Bohemine | CDK |
| Bohemine is A selective CDK inhibitor with IC50 of 4.6 μM, 83 μM and 2.7 μM against Cdk2/ Cyclin E, Cdk2/ Cyclin A and Cdk9/cyclin T1, respectively. Bohemine also inhibited ERK2, IC50 was 52 μM, and inhibited CDK1, CDK4 and CDK6. Bohemine is also a purine analogue and has a wide range of anticancer activities. | ||
| M8666 | Urolithin A | ERK |
| Urolithin A is a naturally occurring compound produced by the metabolism in the body of vegetable tannins (ellagic acid and ellagitannins) found in food. It is also a mitochondrial modulator, regulating mitochondrial function in hematopoietic stem cells, as well as restoring blood regeneration in aging hematopoietic stem cells. In addition, Urolithin A is a ligand for the Aromatic Hydrocarbon Receptor (AhR), which promotes the anti-tumor function of CD8+ cytotoxic T-lymphocytes (CTLs) in an AhR-independent manner. Moreover, Urolithin A directly binds to ERK1/2 kinase, enhances its activation, and subsequently phosphorylates and activates the autophagy initiation factor ULK1, thereby promoting autophagy. | ||
| M10741 | ERK1/2 inhibitor 2 | ERK |
| ERK1/2 inhibitor 2 (Example 1) is a potent dual ERK1/2 inhibitor. ERK1/2 inhibitor 2 has anti-cancer activity. | ||
| M11529 | Temuterkib | ERK |
| LY3214996 | ||
| Temuterkib (LY3214996) is a selective, novel erK1/2 inhibitor with an IC50 of 5 nM against ERK1 and ERK2. It can effectively inhibit intracellular P-RSK1 in cancer cell lines with BRAF and RAS mutations. Temuterkib has strong antitumor activity in cancer models with altered MAPK pathways. | ||
| M14154 | Magnolin | ERK |
| Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively. | ||
| M21071 | MAP855 | MEK |
| MAP855 is a potent, selective and orally effective ATP-competitive MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM). MAP855 inhibits wild-type and mutant MEK1/2 equally. | ||
| M30350 | E6201 | MEK |
| ER-806201 | ||
| E6201 (ER-806201) is an ATP-competitive dual kinase inhibitor of MEK1 and FLT3. E6201 inhibits MEK1- induced ERK2 phosphorylation with an IC50 value of 5.2 nM, MKK4-induced JNK phosphorylation with an IC50 value of 91 nM, and MKK6-induced p38 MAPK phosphorylation with an IC50 value of 19 nM. Anti-tumor and anti-psoriasis efficacy. | ||
| M39049 | Enniatin B1 | Transferase |
| Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes. Enniatin B1 can cross the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation. | ||
| M42116 | ERK-IN-7 | ERK |
| ERK-IN-7, an analogue of SHR2415, is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively. | ||
| M42119 | ERK1/2 inhibitor 9 | ERK |
| ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. | ||
| M45287 | CK2/ERK8-IN-1 | Casein Kinase |
| CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki 0.25 µM) and ERK8 (MAPK15, ERK7), both with IC50s of 0.50 µM. In addition, CK2/ERK8-IN-1 binds to PIM1, HIPK2, and DYRK1A with Ki values of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. 15.25 µM and 11.9 µM, respectively, and also has pro-apoptotic activity. | ||
| M49701 | ERK1/2 inhibitor 3 | ERK |
| ERK1/2 inhibitor 3 is a potent inhibitor of ERK1/2. | ||
| M49702 | ERK1/2 inhibitor 4 | ERK |
| ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. | ||
| M49703 | ERK1/2 inhibitor 5 | ERK |
| ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. | ||
| M49704 | ERK1/2 inhibitor 6 | ERK |
| ERK1/2 inhibitor 6 is a potent inhibitor of ERK1/2. | ||
| M49707 | ERK2-IN-3 | ERK |
| ERK2-IN-3 is a inhibitor of ERK2, and inhibits Erk2WT and Erk2DS1 activation loop phosphorylation, with IC50 of 5 μM and 42 nM, respectively. | ||
| M49720 | STE-MEK1(13) | ERK |
| STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH?) is a cell permeable ERK1/2 inhibitor (IC50: 13-30?μM). | ||
| M49721 | TAT-MEK1 | ERK |
| TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
